NT-3 AND MEDULLOBLASTOMA

摘要

The invention relates to the discovery that nearly all medulloblastomas express neurotrophin-3 (NT-3) and its specific receptor TrkC. NT-3 was found to promote apoptosis in some medulloblastomas, therefore differing from the biologic actions most commonly described for neurotrophins. Based on these findings, the invention discloses methods of analyzing a medulloblastoma and for identifying molecules for treatment of medulloblastoma.