发明名称 |
METHOD AND COMPOSITION FOR MODULATING AMYLOIDOSIS |
摘要 |
Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that modulation of amyloid deposition occurs. Methods also include administering an effective amount of at least one ABC transporter blocker, or a pharmaceutically acceptable salt thereof, to a subject such that a disease state associated with amyloidosis is treated. Packaged pharmaceutical compositions for treating amyloidosis are described. The package includes a container for holding an effective amount of a pharmaceutical composition and instructions for using the pharmaceutical composition for treatment of amyloidosis. The pharmaceutical composition includes at least one ABC blocker for modulating amyloid deposition in a subject. Methods for identifying agent which modulate amyloid deposition in a subject are also described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to an organism, such that modulation of amyloid deposition occurs. |
申请公布号 |
WO9848784(A3) |
申请公布日期 |
1999.08.12 |
申请号 |
WO1998US08463 |
申请日期 |
1998.04.28 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA;REINER, PETER, B.;LAM, FRED, CHIU-LAI |
发明人 |
REINER, PETER, B.;LAM, FRED, CHIU-LAI |
分类号 |
A61K45/00;A61K31/138;A61K31/277;A61K31/352;A61K31/4045;A61K31/407;A61K31/435;A61K31/4433;A61K31/46;A61K31/47;A61K31/473;A61K31/475;A61K31/49;A61K31/5415;A61K38/13;A61P25/28;A61P43/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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