THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF

摘要

Disclosed are crystals, crystal structure Fc gamma RIIa protein, three-dimensional coordinates of Fc gamma RIIa protein, and structures and models derived from the Fc gamma RIIa structure. Also disclosed are crystals of Fc epsilon RI protein and three-dimensional coordinates of Fc epsilon RI protein monomers and dimers derived from the Fc gamma RIIa structure. Also disclosed are three-dimensional coordinates of Fc gamma RIIIb proteins and models of Fc gamma RIIIb derived from the Fc gamma RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.