| 摘要 |
<p>Safety-catch linkers and methods for use of safety-catch linkers in solid phase and combinatorial solid phase synthesis are provided. Safety-catch linkers covalently bonded to solid supports are also provided. The safety-catch linkers are stable to a wide variety of synthetic protocols so that substrates, such as amines, thiols and alcohols, are cleaved from the linkers under mild conditions. The safety-catch linkers are useful in solid phase synthesis and modification of natural products and other complex organic substrates.</p> |
