| 摘要 |
<p>The object of the present invention are novel compounds of azetidine-2-one substituted in 1-position with different isothiazolidinone radicals, as analogons of a beta-lactam structure, of the general formula I <CHEM> wherein R<1> represents a hydrogen or a halo atom, R<2> represents a hydrogen or a halo atom or a phthalimide group, R<3> represents a hydrogen or a halo atom, R<4> represents a hydrogen or a halo atom, R<5> represents a hydrogen atom, a lower linear or branched alkyl, aryl or aralkyl, or a radical containing a heterocycle with one or more heteroatoms, such as isoxazolyl or pyrazolyl, and n is 0, 1 or 2. The usefulness of these compounds as intermediates for the preparation of novel beta-lactam analogons or active substances in formulations for antimicrobial therapy is given.</p> |
