Macrophage inflammatory protein variants

摘要

PCT No. PCT/GB94/00822 Sec. 371 Date Jan. 29, 1996 Sec. 102(e) Date Jan. 29, 1996 PCT Filed Apr. 19, 1994 PCT Pub. No. WO94/24285 PCT Pub. Date Oct. 27, 1994The present invention provides a Stem Cell Inhibitor (SCT) protein which comprises at least one amino acid alteration from its active form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity. The alteration is preferably a conservative substitution of a charged amino acid residue. Such proteins may be used in treating stem cells in a patient undergoing chemotherapy.