| 摘要 |
FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to novel cephalosporins and complexes carbocephalosporin/para-aminobenzoic acid, methods of their synthesis, isolation and purification of antibiotics containing beta-lactam ring. Invention describes complexes of the formula (I) <EMI ID=0.196 HE=30 WI=75 TI=CHI> where X means chlorine, hydrogen atom, vinyl or -CH<SB>3</SB>; Z means CH<SB>2</SB>, S- or O-atom; n = 0-5; Y means phenyl or 1,4-cyclohexadiene-1-yl; R<SB>1</SB> and R<SB>2</SB> mean hydrogen atom or hydroxy-group at condition the they both (R<SB>1</SB> and R<SB>2</SB>) are not hydrogen atom; and R<SB>3</SB> means -COOH, -COO-(C<SB>1</SB>-C<SB>4</SB>)-alkyl or <EMI ID=0.197 HE=12 WI=9 TI=CHI> where R<SB>4</SB> means C<SB>1</SB>-C<SB>4</SB>-alkyl. EFFECT: new cephalosporins and complexes indicated above. 6 cl, 1 tbl, 19 ex
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