DNA and protein for the diagnosis and treatment of Alzheimer's disease

摘要

The present invention relates to a DNA selected from DNAs, each having the nucleotide sequence of one of Sequence Nos. 1 to 17, complementary to the RNA strand of mRNA with the varied expression level in patients with Alzheimer's disease, compared with the expression level of the mRNA in normal human brain or a DNA hybridizable with the above-mentioned DNA wherein one or more nucleotides in said DNA are deleted or substituted with other nucleotides or one or more nucleotides are added to said DNA, a polypeptide encoded by the DNA, an antibody recognizing the polypeptide, and the diagnosis, therapeutic treatment and research works of patients with Alzheimer's disease, using the DNA, the polypeptide and the antibody.