发明名称 |
Method for detecting a predisposition to susceptibility to toxic effects of drugs and poisons |
摘要 |
The present invention relates to methods for diagnosis of susceptibility to neurotoxicity or the pathological effects of neurotoxicity based on detection of a genetic marker in an individual. The present invention is directed generally to methods and associated compositions and kits for detecting the presence of arylsulfatase A (ASA) pseudodeficiency (PD) mutations in humans. Detection of these mutations has been surprisingly found to be a strong indicator for susceptibility to neurotoxicity and/or susceptibility to toxicant's pathological effects, as well as an important marker in evaluating the likelihood of metachromatic leukodystrophy (MLD).
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申请公布号 |
US5935790(A) |
申请公布日期 |
1999.08.10 |
申请号 |
US19970910443 |
申请日期 |
1997.08.05 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY;UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY |
发明人 |
PORETZ, RONALD D.;MANOWITZ, PAUL |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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