发明名称 |
Gene therapy for effector cell regulation |
摘要 |
The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes and/or natural killer cells, in the animal. Therapeutic compositions of the present invention include superantigen-encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule and/or chemokine-encoding nucleic acid molecules, depending upon the disease being treated. The present invention also relates to an adjuvant for use with nucleic acid-based vaccines. Adjuvant compositions of the present invention include an immunogen combined with superantigen-encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule and/or chemokine-encoding nucleic acid molecules.
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申请公布号 |
US5935568(A) |
申请公布日期 |
1999.08.10 |
申请号 |
US19950580806 |
申请日期 |
1995.12.29 |
申请人 |
NATIONAL JEWISH MEDICAL & RESEARCH CENTER |
发明人 |
DOW, STEVE W.;ELMSLIE, ROBYN E.;POTTER, TERENCE A. |
分类号 |
C12N15/09;A61K38/00;A61K38/22;A61K39/00;A61K39/002;A61K39/04;A61K39/085;A61K39/09;A61K39/12;A61K39/205;A61K39/21;A61K39/245;A61K39/39;A61K48/00;A61P31/00;A61P31/04;A61P31/12;A61P35/00;A61P35/02;A61P37/00;C07K14/31;C07K14/35;C12N15/62;(IPC1-7):A61K48/00;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
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