Substituted vinyl pyridine derivative and drugs containing the same

摘要

PCT No. PCT/JP97/03354 Sec. 371 Date May 26, 1998 Sec. 102(e) Date May 26, 1998 PCT Filed Sep. 22, 1997 PCT Pub. No. WO98/13348 PCT Pub. Date Apr. 2, 1998The present invention relates to a substituted vinylpyridine derivative represented by the following formula (1): (wherein R1 represents a hydrogen atom, an alkyl group, etc., R2 represents an alkyl group; one of R3 and R4, which are different from each other, represents a hydrogen atom and the other represents a nitrile group, R5 represents an aryl group or a heteroaryl group, X represents an oxygen atom, etc., and one of Q1, Q2, and Q3 represents a nitrogen atom and the other two represent CH); a salt of the derivative; and a drug containing the derivative or salt as the active ingredient. Due to strong PDE inhibitory action and TNF- alpha production inhibitory action, the derivative, salt, and drug are useful for the prevention and treatment of a wide variety of inflammatory diseases and autoimmune diseases.