| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new compounds of the formula (I) where each of R and R means independently hydrogen atom or -CO(CR<SP>3</SP>R<SP>4</SP>)<SB>b</SB>(CR<SP>5</SP>R<SP>6</SP>)<SB>d</SB>CR<SP>7</SP>R<SP>8</SP>R where each of R and R means independently hydrogen atom, alkyl with 1-6 carbon atoms; each of R and R means independently hydrogen atom, alkyl with 1-6 carbon atoms or R and R can form in common the group X or cycloalkyl ring with 3-8 carbon atoms; R means hydrogen atom, alkyl with 1-6 carbon atoms; each of R and R means independently hydrogen atom, alkyl with 1-6 carbon atoms, -(CR<SP>3</SP>R<SP>4</SP>)<SB>f</SB>OR or R and R can in common form groups X or cycloalkyl ring with 3-8 carbon atoms; R means hydrogen atom, alkyl with 1-6 carbon atoms, tri (alkyl) with 1-6 carbon atoms silyl, tri (alkyl) with 1-6 carbon atoms silylethyl or tetrahydropyranyl; X means 5-[(2,2-di(alkyl] c 1-6 carbon atoms (1,3)-dioxanyl, 5-(2-spirocycloalkyl) with 3-8 carbon atoms (1,3)-dioxanyl, 4-[2,2-di(alkyl)] with 1-6 carbon atoms (1,3)-dioxanyl, 4-[2-spiro(cycloalkyl)] with 3-8 carbon atoms (1,3)-dioxanyl; b = 0-6; d = 0-6; f = 0-6 at condition that R and R are not hydrogen atom simultaneously and either R or R has at least one (CR<SP>3</SP>R<SP>4</SP>)<SB>f</SB>OR , X or cycloalkyl with 3-8 carbon atoms. Pharmaceutically acceptable salt of this compound is used as an immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumor agent. Invention describes also a method of synthesis of compounds of the formula (I) showing immunosuppressive activity and a method of treatment of patients using compounds of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 22 cl, 14 ex
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