PROCESS FOR PRODUCING NUCLEOSIDE DERIVATIVES

摘要

A process for conveniently and industrially producing nucleoside derivatives wherein 9-(2,3-dideoxy-2-fluoro--D-threo-pentofuranosyl) adenine (FddA), etc. have been substituted at the 2'-position by a fluorine atom, etc. and deoxidized at the 3'-position and compounds related thereto. This process comprises halogenating purine riboside at the 6-position by a halogen atom, modifying the 3'- and 5'-positions of the saccharide moiety thereof with protective groups which cannot be deblocked under the same conditions, further introducing a desired protective group (a fluorine atom, etc.) into the 2'position of the saccharide moiety and then deblocking-deoxidizing the same at the 3'-position. Processes for producing important intermediates usable in the above process and novel intermediates are also provided.