ERYTHROPOIETIN WITH ALTERED BIOLOGICAL ACTIVITY

摘要

The invention relates to DNA encoding modified, secretable erythropoietin proteins whose ability to regulate the growth and differentiation of red blood cell progenitors are different from the wildtype recombinant erythropoietin. The invention also relates to methods of modifying or altering the regulating activity of the secretable erythropoietin proteins and the use of the modified secretable erythropoietin proteins, for example, in in vivo therapeutics.