发明名称 Pharmaceutical composition of hedgehog proteins and use thereof.
摘要 A pharmaceutical mixture made from hedgehog proteins where hedgehog proteins are bound to a biologically appropriate carrier, which absorbs water. This carrier is a polymer and,- binds the hedgehog proteins as a negatively charged carrier as the result of the ionic interactions,- when a hedgehog protein is bound to carrier, this doesn't modify the protein.- under neutral conditions, it includes per monomer at least 0.1 to 2 negative residuum.- it includes loading in the form of acidic groups.- average molecular weight is at least 50.000Da.- and it doesn't include agarose.It is possible in vivo form to reverse this connection of hedgehog proteins from a carrier and release it in active form.
申请公布号 ZA9900887(B) 申请公布日期 1999.08.04
申请号 ZA19990000887 申请日期 1999.02.04
申请人 BOEHRINGER MANNHEIM GMBH 发明人 KURT LANG;APOLLON PAPADIMITRIOU
分类号 A61K;A61K9/22;A61K31/728;A61K38/00;A61K38/17;A61K38/39;A61K47/02;A61K47/26;A61K47/48;A61P19/08;C07K14/00;C12N5/00;C12P21/00 主分类号 A61K
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