Ansamycin derivatives as antioncogene and anticancer agents

摘要

PCT No. PCT/IB94/00160 Sec. 371 Date Mar. 25, 1996 Sec. 102(e) Date Mar. 25, 1996 PCT Filed Jun. 16, 1994 PCT Pub. No. WO95/01342 PCT Pub. Date Jan. 12, 1995A compound of the formula and pharmaceutically acceptable salts and prodrugs thereof wherein R1, R2, R3, R4, R5 and R6 are as defined below, methods and intermediates useful in the preparation thereof, pharmaceutical compositions thereof and methods of treatment therewith. The compounds of the above formula are useful in inhibiting oncogene products and as antitumor and anticancer agents.