摘要 |
PROBLEM TO BE SOLVED: To produce the subject new derivative comprising a specific phthalaldenyde derivative, capable of suppressing glucose-6-phosphate translocase and useful for producing a prophylactic and therapeutic agent, etc., for glucose dysmetabolism of a human body, especially for producing a therapeutic agent, etc., for diabetes mellitus. SOLUTION: This new phthalaldehyde derivative (salt) is represented by the formula (R<1> and R<2> are each H, a 1-4C alkyl, a 1-4C alkenyl or a 1-4C acyl; R<3> is a 1-4C alkyl, a 1-4C alkenyl, OH, OR<1> , SR<1> or NR<1> R<2> ; R<4> to R<9> are each H or methyl) [e.g. flavipin (3,4,5-trihydroxy-6-methyl-o-phthalaldehyde)] and is useful for producing a prophylactic and therapeutic agent for glucose dysmetabolism of a human body, especially for producing a therapeutic agent, etc., for diabetes mellitus. The compound is produced by culturing Hericium erinaceus DSM 10600 which is a basidiomycetous strain in a nutrient solution containing a carbon source, a nitrogen source and a usual inorganic salt. |