| 发明名称 |
Modulation of drug resistance via ubiquitin carboxy-terminal hydrolase |
| 摘要 |
The expression of ubiquitin carboxy-terminal hydrolase is aberrent in cells that are resistant to treatment with chemical agents. Accordingly, the invention features methods for diagnosing and treating drug resistant cells (e.g., tumor cells) by examining and modulating the expression or activity of UCH.
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| 申请公布号 |
US5932422(A) |
申请公布日期 |
1999.08.03 |
| 申请号 |
US19970970733 |
申请日期 |
1997.11.14 |
| 申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
SHYJAN, ANDREW W.;MACBETH, KYLE J. |
| 分类号 |
A61K38/00;A61K48/00;A61P37/00;C12N1/19;C12N9/16;G01N33/50;(IPC1-7):C12Q1/68;C12N15/63;C07H21/04 |
主分类号 |
A61K38/00 |
| 代理机构 |
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