发明名称 |
Methods and compositions for the monitoring and quantitation of minimal residual disease in hematopoietic tumors |
摘要 |
Methods and compositions for monitoring the presence of minimal residual hematopoietic tumor cells, such as T-cell acute lymphoblastic leukemia cells, in remission cells of a patient. The invention relates to using nucleic acid hybridization probes to detect alteration of tal-1 locus on chromosome 1 from a DNA extract to confirm the presence of residual T-cell acute lymphoblastic leukemia cells in the patient. Methods to quantitate the amount of hematopoietic cells are described. Kits for detecting and monitoring hematopoietic tumor cells in a patient are provided. Kits for quantitating hematopoietic tumor cells in a patient in remission are also provided.
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申请公布号 |
US5932414(A) |
申请公布日期 |
1999.08.03 |
申请号 |
US19950405373 |
申请日期 |
1995.03.15 |
申请人 |
UNIVERSITY OF TEXAS SYSTEMS BOARD OF REGENTS |
发明人 |
SMITH, R. GRAHAM;BAER, RICHARD J. |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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