| 发明名称 |
Treatment of hyperandrogenic conditions |
| 摘要 |
PCT No. PCT/US96/16871 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Oct. 22, 1996 PCT Pub. No. WO97/15305 PCT Pub. Date May 1, 1997The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5 alpha -reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5 alpha -reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.
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| 申请公布号 |
US5932559(A) |
申请公布日期 |
1999.08.03 |
| 申请号 |
US19980051948 |
申请日期 |
1998.04.23 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
BULL, HERB G.;HARRIS, GEORGIANNA;MYERS, ROBERT W. |
| 分类号 |
C07C217/52;C07C229/48;C07C233/81;C07C237/06;C07D207/16;C07D207/26;C07D209/08;C07D211/14;C07D211/58;C07D211/62;C07D213/38;C07D213/61;C07D215/18;C07D215/20;C07D233/86;C07D239/26;C07D249/08;C07D249/12;C07D257/04;C07D261/08;C11D3/395;C11D17/00;(IPC1-7):A61K31/505;C07D471/02 |
主分类号 |
C07C217/52 |
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