The use of increased neurofilament protein levels as protection and therapy against neurodegeneration with oxidative stress involvement

摘要

The present invention describes the use of increased levels of NF proteins to provide protection against reactive oxygen species and neurodegeneration associated with oxidative stress. The neurodegeneration associated with oxidative stress may be due to aging, injury, or neurodegenerative disorders, such as Amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Giant Axonal Neuropathy, neuropathies associated with diabetes, toxic neuropathies, Lewy body Dementia, or Guam-Parkinsonism.