发明名称 Aminosulphonylbenzamide derivatives as modulators of the activity of neuronal calcium channels
摘要 A pharmaceutical compound of formula (I) in which the aminosulfonyl group is attached at the 3- or 4-position, and in which R<1> is hydrogen, C1-6 Alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl or optionally substituted phenyl-C1-4 alkyl, R<2> is C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, optionally substituted phenyl-C1-4 alkyl or -(CH2)2NR<5>R<6> where R<5> and R<6> are each hydrogen or C1-6 alkyl, and R<3> and R<4> are each C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, C3-6 alkenyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl, or R<1> and R<2>, or R<3> and R<4>, or R<5> and R<6>, together with the nitrogen atom to which they are attached, form a carbocyclic group containing 4 to 7 carbon atoms optionally substituted with one to three methyl or ethyl groups and optionally containing an oxygen atom or a further nitrogen atom, said carbocyclic group being optionally fused to an optionally substituted phenyl group; or a salt thereof.
申请公布号 AU2172899(A) 申请公布日期 1999.08.02
申请号 AU19990021728 申请日期 1999.01.13
申请人 ELI LILLY AND COMPANY LIMITED 发明人 SANDRA MILUTINOVIC;ROBIN GEORGE SIMMONDS;DAVID EDWARD TUPPER
分类号 C07D295/22;A61K31/18;A61K31/40;A61K31/445;A61K31/4453;A61K31/5375;A61P25/00;A61P43/00;C07C311/16;C07D207/09;C07D211/96;C07D217/06;C07D295/185;C07D295/26 主分类号 C07D295/22
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