METHOD FOR DETERMINING GENE ESSENTIALITY IN A PATHOGEN
摘要
The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.
申请公布号
WO9937330(A1)
申请公布日期
1999.07.29
申请号
WO1999US01278
申请日期
1999.01.21
申请人
SMITHKLINE BEECHAM CORPORATION;PALMER, LESLIE, M.;PRATT, JULIE, M.;ROSENBERG, MARTIN
发明人
PALMER, LESLIE, M.;PRATT, JULIE, M.;ROSENBERG, MARTIN