摘要 |
A class of substituted 1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing a fluoro-substituted phenyl ring at the 3-position and a heteroaryl-methoxy moiety at the 6-position, are selective ligands for GABAA receptors, in particular having high affinity for the alpha 2 and/or alpha 3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
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申请人 |
MERCK SHARP & DOHME LIMITED;CARLING, WILLIAM, ROBERT;CASTRO PINEIRO, JOSE LUIS;COLLINS, IAN, JAMES;GUIBLIN, ALEXANDER, RICHARD;HARRISON, TIMOTHY;MADIN, ANDREW;MOORE, KEVIN, WILLIAM;RUSSELL, MICHAEL, GEOFFREY, NEIL;SCOTT, GAYLE;STREET, LESLIE, JOSEPH |
发明人 |
CARLING, WILLIAM, ROBERT;CASTRO PINEIRO, JOSE LUIS;COLLINS, IAN, JAMES;GUIBLIN, ALEXANDER, RICHARD;HARRISON, TIMOTHY;MADIN, ANDREW;MOORE, KEVIN, WILLIAM;RUSSELL, MICHAEL, GEOFFREY, NEIL;SCOTT, GAYLE;STREET, LESLIE, JOSEPH |