2,3-BENZODIAZEPIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF PROTEIN TYROSINE KINASES

摘要

Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. A compound represented by structural formula (I), where R1, R2 and R3 are independently described as Y bonded to W, where Y is a 0-6 atom straight or branched saturated or unsaturated chain group comprising C, N, O or S as shown in Table 1, and W is hydrogen or any three membered, four membered, five membered, six membered or fused bicyclic ring system comprising C, N, O or S as shown in Tables 4-9; X is separately and independently selected from Table 2; and salts of said compound. Methods are provided for inhibition of specific protein tyrosine kinases, for example pp60. Methods are further provided for the use of these inhibitors in situations where the inhibition of a protein tyrosine kinase is indicated, for example, in the treatment of certain diseases in mammals, including humans.