MONOCLONAL ANTIBODY ANTI .ALPHA.V-INTEGRIN AND ITS USE TO INHIBIT .ALPHA.V.BETA.6-INTEGRIN ATTACHMENT TO FIBRONECTIN

摘要

The invention relates to a novel monoclonal antibody and a hybridoma cell line producing said antibody. The monoclonal antibody, a preferred embodiment of which is named 14D9.F8, has the following properties: reacting only with the .alpha.v-chain of human .alpha.v-integrins, and inhibiting selectively the attachment to the integrin substrate fibronectin of the .alpha.v.beta.6integrin bearing cell.