摘要 |
<p>N-(substituted aryl) [1,2,4]triazoloazinesulfonamide compounds, such as N-(2,6- difluorophenyl)-8- fluoro-5-methoxy[1,2,4] triazolo[1-5-c] pyrimidine-2-sulfonamide, were prepared at a good reaction rate and in good yield by the reaction of a chlorosulfonyl[1,2,4]triazoloazine compound, such as 2-chlorosulfonyl-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine, and an arylamine compound, such as 2,6-difluoroaniline, in an organic medium containing a relatively acidic alcohol, such as propylene glycol or 2,2,2-trifluoroethanol.</p> |