发明名称 |
PROTEASOME INHIBITORS, UBIQUITIN PATHWAY INHIBITORS OR AGENTS THAT INTERFERE WITH THE ACTIVATION OF NF- kappa B VIA THE UBIQUITIN PROTEASOME PATHWAY TO TREAT INFLAMMATORY AND AUTOIMMUNE DISEASES |
摘要 |
This invention is directed to the treatment of inflammatory and autoimmune diseases by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF- kappa B via the ubiquitin proteasome pathway, or mixtures thereof. The invention is further directed to the treatment of inflammatory and autoimmune diseases by administering an effective combination of a glucocorticoid and a proteasome inhibitor, ubiquitin pathway inhibitor, agent that interferes with the activation of NF- kappa B via the ubiquitin proteasome pathway, or mixture thereof. Pharmaceutical compositions comprising a combination of a glucocorticoid and a proteasome inhibitor, ubiquitin pathway inhibitor, agent that interferes with the activation of NF- kappa B via the ubiquitin proteasome pathway, or mixture thereof are also contemplated within the scope of the invention.
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申请公布号 |
WO9915183(A9) |
申请公布日期 |
1999.07.29 |
申请号 |
WO1998US20065 |
申请日期 |
1998.09.25 |
申请人 |
PROSCRIPT INC.;ELLIOT, PETER;ADAMS, JULIAN;PLAMONDON, LOUIS |
发明人 |
ELLIOT, PETER;ADAMS, JULIAN;PLAMONDON, LOUIS |
分类号 |
A61K45/00;A61K31/16;A61K31/407;A61K31/573;A61K45/06;A61P11/06;(IPC1-7):A61K31/69;A61K31/40 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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