| 摘要 |
Method to identify agonist or inhibitory antibodies to receptors involved in cellular proliferation, differentiation, survival or activation comprising the steps of immunizing an animal with stem/progenitor cells having surface molecules comprising the receptors, so as to generate a plurality of cells expressing one or more antibodies to the surface molecules, creating a library from the plurality of cells, comprising nucleic acid sequences encoding the antibodies, cloning the nucleic acid sequences from the library into surface display vectors so that the antibodies are surface displayed, and screening the surface displayed antibodies using target cells to identify agonist or inhibitory antibodies to the receptors.
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