| 发明名称 |
MODIFIED ENZYMES AND THEIR USE FOR PEPTIDE SYNTHESIS |
| 摘要 |
The present invention relates to modified enzymes with one or more amino acid residues from an enzyme being replaced by cysteine residues, where at least some of the cysteine residues are modified by replacing thiol hydrogen in the cysteine residue with a thiol side chain to form a modified enzyme, wherein the modified enzyme has high esterase and low amidase activity. Also, a method of producing the modified enzymes is provided. The present invention also relates to a method for using the modified enzymes in peptide synthesis.
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| 申请公布号 |
CA2321169(A1) |
申请公布日期 |
1999.07.29 |
| 申请号 |
CA19992321169 |
申请日期 |
1999.01.21 |
| 申请人 |
GENENCOR INTERNATIONAL, INC. |
发明人 |
JONES, J. BRYAN |
| 分类号 |
C12N15/09;C07K1/02;C07K5/06;C07K5/065;C07K5/068;C07K5/072;C11D3/386;C12N9/16;C12N9/48;C12N9/50;C12N9/54;C12P21/06;(IPC1-7):A61K38/43;C11D3/00;D06M16/00;C12N15/00;C12N9/14;A61K38/46;A61K38/47;A61K38/48;C12N9/52;C12N9/56;C12N9/80 |
主分类号 |
C12N15/09 |
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