发明名称 |
Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof |
摘要 |
<p>A novel permeability enhancing peptide (PEP) is a fragment of interleukin-2. When joined to a delivery vehicle that can target a tumor site, the PEP can increase the subsequent uptake of antineoplastic or tumor imaging agents. The PEP can be chemically joined to a monoclonal antibody to form an immunoconjugate. Alternatively, an expression vector is genetically engineered to express a fusion protein. The fusion protein has an antigen-binding portion joined to the PEP. The PEP is most effective when it takes the form of a dimer, linked by a disulfide bridge. The PEP is substantially free of cytokine activity and produces minimal toxic side effects on normal tissues. <IMAGE> <IMAGE></p> |
申请公布号 |
EP0931836(A1) |
申请公布日期 |
1999.07.28 |
申请号 |
EP19980100603 |
申请日期 |
1998.01.15 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA |
发明人 |
EPSTEIN, ALAN L.;KHAWLI, LESLIE A. |
分类号 |
A61K38/00;A61K47/48;C07K14/55;C07K16/30;C07K19/00;C12N15/26;C12N15/62;G01N33/68;(IPC1-7):C12N15/62 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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