发明名称 |
Composição monomérica biocompatível processo para união entre si in vivo de duas superfícies viventes de tecido para aplicação em tecido vivente de uma composiç o adesiva e para formação de uma película biocompatível e película |
摘要 |
A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) holding damaged tissue edges together to form abutted tissue surfaces; (b) applying to the abutted tissue surfaces an excessive amount of a composition containing 1) at least one monomer, which forms a medically acceptable biodegradable polymer, 2) at least one plasticizing agent; and 3) at least one acidic stabilizing agent; and (c) maintaining the surfaces in contact until the composition polymerizes to form a thick film of polymerized composition bridging the abutted tissue surfaces. |
申请公布号 |
BR9707794(A) |
申请公布日期 |
1999.07.27 |
申请号 |
BR19979707794 |
申请日期 |
1997.02.28 |
申请人 |
CLOSURE MEDICAL CORPORATION |
发明人 |
JEFFREY G. CLARK;JEFFREY C. LEUNG |
分类号 |
A61B5/00;A61L24/00;A61L24/06;C08F2/44;C08F20/42;C08J5/12;C09J4/00;C09J7/00;G01J3/18;(IPC1-7):A61F13/00 |
主分类号 |
A61B5/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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