Adsorptive separation of 3-hydroxytetrahydrofuran enantiomers

摘要

The chiral isomers of 3-hydroxytetrahyrofuran are separated by means of liquid chromatography using a stationary phase comprising a substituted polysaccharide carbamate. The separation may be performed using a simulated moving bed adsorbent system. Suitable mobile phase materials comprise a mixture of a light paraffin and a low molecular weight aliphatic alcohol such as a mixture of n-hexane and ethanol. Amylose is the preferred polysaccharide.