发明名称 |
Isolation, purification and cloning of retinol dehydratase |
摘要 |
The present invention relates to retinol dehydratase, the enzyme which synthesizes the retro-retinoid anhydroretinol in the Spodoptera frugiperda insect cell line Sf-21, as well as the DNA molecule encoding that enzyme. The DNA molecule can be incorporated in a DNA expression system and a host for recombinant production of anhydroretinol dehydratase. The isolated retinol dehydratase protein or polypeptide of the present invention can be combined with a pharmaceutically-acceptable carrier or used alone for administration to mammals, particularly humans, for preventing cell growth and/or uncontrolled cell growth in cells which are growth dependent on retinol and/or 14 hydroxy-4, 14-retro-retinol.
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申请公布号 |
US5928931(A) |
申请公布日期 |
1999.07.27 |
申请号 |
US19970852481 |
申请日期 |
1997.05.07 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC.;SLOAN-KETTERIN INSTITUTE FOR CANCER RESEARCH |
发明人 |
GRUEN, FELIX;BUCK, JOCHEN;HAMMERLING, ULRICH |
分类号 |
A61K38/00;C12N1/21;C12N9/88;C12N15/60;(IPC1-7):C12N15/60;C12N15/63 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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