Regioselective alpha -hydrolysis of amino acid diesters using pig liver esterase

摘要

The regioselective and chemoselective hydrolysis of an alpha -ester group of an amino acid diester using pig liver esterase enzyme (PLE) is disclosed. The amino acid diesters may be either N-protected or unprotected and the diester groups may be the same or different. In particular, the preparation of a number of gamma -ester glutamates and beta -ester aspartates are provided.