摘要 |
The subject invention provides a crystal suitable for X-ray diffraction comprising a polypeptide having an amino acid sequence of a portion of a Human Immunodeficiency Virus envelope glycoprotein gp120. The subject invention also provides the above-described crystals, wherein the crystal is arranged in a space group P2221, so as to form a unit cell of dimensions a=71.6 ANGSTROM , b=88.1 ANGSTROM , c=196.7 ANGSTROM , and which effectively diffracts X-rays for determination of the atomic coordinates of the gp120 to a resolution of 2.5 ANGSTROM or better. The subject invention additionally provides compounds inhibiting the CD4-gp 120 interaction, compounds inhibiting chemokine receptor-gp120 interaction, mimics of CD4, gp120 variants and uses thereof.
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申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;DANA-FARBER CANCER INSTITUTE, INC.;KWONG, PETER, D.;HENDRICKSON, WAYNE, A.;SODROSKI, JOSEPH, G.;WYATT, RICHARD, T. |
发明人 |
KWONG, PETER, D.;HENDRICKSON, WAYNE, A.;SODROSKI, JOSEPH, G.;WYATT, RICHARD, T. |