GTPASE DERIVED FROM HUMAN LYMPH NODES THAT EFFECTS THE MORPHOLOGY AND CYTOSKELETON ORGANIZATION OF ENDOTHELIAL CELLS

摘要

A human GTPase polypeptide intracellular molecular switch is described. A full length cDNA which encodes the signal transduction polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the human GTPase. Methods are provided to identify compounds that modulate the biological activity and/or pharmacological activity of the native signal switch biomolecule and hence regulate cellular and tissue physiology.