发明名称 |
Binding domains in delta proteins |
摘要 |
The present invention provides substantially purified fragments of a Delta protein as well as derivatives and analogs thereof, characterized by the ability in vitro, when expressed on the surface of a first cell to bind to a Notch protein, or a second Delta protein or fragment expressed on the surface of a second cell, the nucleic acid sequences encoding said fragments as well as vectors and recombinant cells containing the same. A method of producing a fragment of a Delta protein is also disclosed. <IMAGE>
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申请公布号 |
EP0930366(A2) |
申请公布日期 |
1999.07.21 |
申请号 |
EP19990101563 |
申请日期 |
1992.05.01 |
申请人 |
YALE UNIVERSITY;INDIANA UNIVERSITY FOUNDATION |
发明人 |
ARTAVANIS-TSAKONAS,SPYRIDON;MUSKAVITCH, MARC,ALAN,TELANDER;FEHON, RICHARD GRANT;SHEPARD, SCOTT, BROCKEWELL |
分类号 |
C12N15/09;A61K38/00;C07K14/47;C07K14/485;C07K14/52;C07K14/705;C07K16/00;C07K16/18;C07K19/00;C12N5/10;C12N15/12;C12P21/02;C12P21/08;C12R1/91;(IPC1-7):C12N15/12;C07K14/435;C12N15/62 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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