| 摘要 |
<p>The present invention relates to novel compounds of the general formula <CHEM> wherein R<1> is hydrogen; R<2> is hydrogen, trifluoromethyl or lower alkyl; R<3> is hydrogen or amino; or R<1> and R<2> or R<3> and R<2> taken together are -CH=CH-CH=CH-; Z is pyrimidin-4-yl, pyridin-4-yl, pyridin-2-yl or phenyl; R<4,> R<5> are each independently hydrogen, lower alkyl, trifluoromethyl, halogen, lower alkoxy, nitrilo, amino, lower alkyl-amino, di-lower alkyl-amino, piperazinyl, morpholinyl, pyrrolidinyl, vinyl, C3-C6 cycloalkyl, C3-C6 cycloalkenyl, t-buthylethinyl, hydroxyalkylethinyl, phenylethinyl, naphthyl, thiophenyl, or phenyl, which may be substituted by halogen, lower alkoxy, lower alkyl, trifluoromethyl or nitro, or a group -NH(CH2)nNR<6>R<7>, -N(CH3)(CH2)nNR<6>R<7>, -NH(CH2)n-morpholin-4-yl or -NH(CH2)nOH; n is 2-4 R<6> and R<7> are each independently hydrogen or lower alkyl, and to their pharmaceutically acceptable salts. It has been found that the compounds of formula I possess a selective affinity to 5HT-6 receptors.</p> |
