FLUORINATED PROSTAGLANDIN DERIVATIVES AND MEDICINES

摘要

A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: <CHEM> wherein A is a vinylene group, an ethylene group, an ethynylene group or the like, R<1> is an aryloxyalkyl group, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aralkyl group or the like, R<2> and R<3> are hydrogen atoms, acyl groups or the like, Z is OR<4>, -NHCOR<5>, -NHSO2R<6>, -SR<7>, (wherein R<4>, R<5>, R<6> and R<7> are hydrogen atoms, alkyl groups or the like) or the like, and a dual line consisting of solid and broken lines is a single bond, a cis-double bond or a trans-double bond. The medicine is an excellent medicine for an eye disease which has a high pharmacological action and little side effect.