PRODUCTION OF L-LYSINE BY FERMENTATION

摘要

PROBLEM TO BE SOLVED: To provide a method for producing L-lysine by a more improved fermented method than a conventional method, by elucidating the order of the velocity controlling steps of L-lysine biosynthesis system. SOLUTION: A bacterium belonging to the genus Escherichia which is transformed with a DNA encoding dihydrodipicolinate not to be subjected to feed back inhibition with L-lysine and a DNA encoding asphalt kinase III not to be subjected to feed back inhibition with L-lysine by transferring them into a cell, and enhanced by a dihydrodipicolinic acid reductase gene (and tetrahydrodipicolinic acid succinylase gene and succinyldiaminopimelate deacylase gene) in a preferable medium. L-Lysine is produced and accumulated in the culture and L-lysine is collected from the culture.