摘要 |
PCT No. PCT/GB95/03049 Sec. 371 Date Jun. 25, 1997 Sec. 102(e) Date Jun. 25, 1997 PCT Filed Dec. 29, 1995 PCT Pub. No. WO96/20935 PCT Pub. Date Jul. 11, 1996Lamotrigine, 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, may be prepared by treating 6-(2,3-dichlorophenyl)-5-chloro-3-thiomethyl-1,2,4-triazine of formula (II) with ammonia. Precursors to the compound of formula (II), and their preparation, are also described.
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