发明名称 Benzopyran and benzothiopyran derivatives having retinoid antagonist-like activity
摘要 2,2-Dialkyl-4-aryl-substituted benzopyran and benzothiopyran derivatives of the formula where the symbols have the meaning described in the specification, have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists can be administered to mammals, including humans, for the purpose of preventing or diminishing action of RAR agonists on the bound receptor sites. Specifically, the RAR agonists are administered or coadministered with retinoid drugs to prevent or ameliorate toxicity or side effects caused by retinoids or vitamin A or vitamin A precursors. The retinoid negative hormones can be used to potentiate the activities of other retinoids and nuclear receptor agonists.
申请公布号 AU1940699(A) 申请公布日期 1999.07.19
申请号 AU19990019406 申请日期 1998.12.21
申请人 ALLERGAN SALES, INC. 发明人 ELLIOTT S. KLEIN;ALAN T JOHNSON;ANDREW M. STANDEVEN;RICHARD L BEARD;SAMUEL J GILLETT;TIEN T DUONG;SUNIL NAGPAL;VIDYASAGAR VULIGONDA;MIN TENG;ROSHANTHA A CHANDRARATNA
分类号 A61K31/165;A61K31/19;A61K31/192;A61K31/216;A61K31/341;A61K31/35;A61K31/352;A61K31/353;A61K31/382;A61K31/426;A61K31/427;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4418;A61K31/4433;A61K31/4436;A61K31/47;A61K31/655;A61P3/06;A61P17/00;A61P19/00;A61P25/04;A61P39/02;C07C63/06;C07C65/38;C07C69/78;C07C233/65;C07D213/55;C07D215/14;C07D233/66;C07D277/20;C07D277/30;C07D307/54;C07D311/04;C07D311/58;C07D333/24;C07D335/06;C07D401/12;C07D405/06;C07D409/04;C07D409/14;C07D417/04;C07F7/04 主分类号 A61K31/165
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