PHENYLALANINE DERIVATIVES

摘要

Phenylalanine derivatives of formula (1) are described, in which L<1> is a linker atom or group; A is a chain -[C(R<7>)(R<8>)]pY[C(R<9>)(R<10>)]q- in which Y is a sulphur atom or a -S(O)- or -S(O)2- group, R<7>, R<8>, R<9> and R<10>, which may be the same or different, is each a hydrogen atom or a straight or branched alkyl or optionally substituted aromatic group, or R<7> and R<8> together with the carbon atom to which they are attached, or R<9> and R<10> together with the carbon atom to which they are attached, each forms a C3-7cycloalkyl group, and p and q, which may be the same or different, is each zero or an integer 1 or 2, provided that when one of p or q is zero the other is an integer 1 or 2; L<2> is a linker group selected from -C(O)-, -C(O)O-, -C(S)-, -S(O)2-, -CON(R<11>)-, [where R<11> is a hydrogen atom or a straight or branched alkyl group], -CSN(R<11>)-, -SON(R<11>)- or SO2N(R<11>)-; R is a carboxylic acid or a derivative thereof; and the salts, solvates and hydrates thereof. The compounds are able to inhibit the binding of alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.