PROMOTING MOBILIZATION AND CATABOLISM OF LIPIDS

摘要

Methods and compositions for mobilization and catabolism of lipids in a subject. A lipolytic agent is administered to mobilize lipids together with a substrate for an energy-consuming chemical-reaction in the body that activates the energy-consuming reaction to thereby promote the catabolysis of the mobilized lipids. Lipolytic agents include xanthines, indirect sympathomimetic amines and precursors for norepinephrine and for histamine. The substrates include amino acids that are metabolized to form ammonia and amino acids involved in either or both the glutamine-glutamate and urea reaction cycles, such as glutamine, glutamic acid, aspartic acid, glycine, histidine, arginine, citrulline, ornithine. Glucagon secretion is additionally promoted, to further effect lipolysis, through the administration of ornithine and arginine, which also function as substrates. Glucagon secretion is also promoted by administering limited quantities of mono- and di-saccharides.