发明名称 |
Triazolopyridazine als Antiasthmatika |
摘要 |
Novel compound represented by the formula: <CHEM> wherein R<1> stands for H, an optionally substituted lower alkyl group or a halogen; R<2> and R<3> respectively stands for a hydrogen or an optionally substituted lower alkyl group, or R<2> and R<3> may, taken together with the adjacent -C=C- group, form a 5- to 7-membered ring; X stands for O, SO or SO2; Y stands for a group of the formula: <CHEM> (R<4> and R<5> respectively stand for H or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R<6> and R<7> each stands for H, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R<6> and R<7> may, taken together with the adjacent N, form an optionally substituted N-containing heterocyclic group; m stands for 0 to 4; n stands for 0 to 4, or a salt thereof, which has excellent anti-PAF activities anti-LTC4 activities and anti-ET-1 activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmasceutical compositions. |
申请公布号 |
DE69325199(D1) |
申请公布日期 |
1999.07.15 |
申请号 |
DE1993625199 |
申请日期 |
1993.03.17 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD., OSAKA, JP |
发明人 |
MIYAKE, AKIO, OSAKA 573, JP;KAWANO, YASUHIKO, OSAKA 565, JP;ASHIDA, ASUKO, OSAKA 569, JP |
分类号 |
A61K;A61K31/50;A61K31/5025;A61P7/02;A61P29/00;A61P37/08;C07D;C07D487/04 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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