发明名称 |
GENE THERAPY OF TUMORS USING NON-VIRAL DELIVERY SYSTEM |
摘要 |
The present invention provides a pharmaceutical composition comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and 1,2-diacyl-sn-glycero-3-phosphoethanolamine; and (b) a plasmid cDNA sequence encoding a protein having tumor suppressor or pro-apoptotic activity. This composition has a high gene transfection efficiency at non-toxic doses and is designed to transfect human bronchial premalignant lesions and early endobronchial malignancies. Also provided is a method of treating a cancerous or pre-cancerous condition of the respiratory tract in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a pharmaceutical composition comprising: (a) cationic lipids, wherein said lipids are a liposomal mixture of a diacyl-ethyl-phosphocholine and 1,2-diacyl-sn-glycero-3-phosphoethanolamine; and (b) a plasmid cDNA sequence encoding a protein having tumor suppressor or pro-apoptotic activity.
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申请公布号 |
WO9934835(A1) |
申请公布日期 |
1999.07.15 |
申请号 |
WO1999US00262 |
申请日期 |
1999.01.06 |
申请人 |
PEREZ-SOLER, ROMAN;ZOU, YIYU |
发明人 |
PEREZ-SOLER, ROMAN;ZOU, YIYU |
分类号 |
A61K9/127;A61K38/17;A61K48/00;(IPC1-7):A61K48/00;C12N15/00;C12N5/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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