发明名称 |
METHOD FOR PRODUCING DOXAZODIN MESYLATE IN A CRYSTAL MODIFICATION DESIGNATED AS FORM A AND INTERMEDIATE PRODUCT FOR PRODUCING THE SAME |
摘要 |
Disclosed is a method for the production of doxazodin mesylate according to modification A, wherein doxazodin is dissolved with methanesulfonic acid in methanol or in a mixture of an aprotic polar organic solvent and methanol. Turbidity is optionally eliminated in the solution thus obtained. The resulting clear solution is stirred until no precipitation occurs and it is then separated and washed with methanol. The wet precipitate is then heated in ethanol and the resulting product is isolated after cooling.
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申请公布号 |
CA2317523(A1) |
申请公布日期 |
1999.07.15 |
申请号 |
CA19982317523 |
申请日期 |
1998.12.18 |
申请人 |
KNOLL AKTIENGESELLSCHAFT |
发明人 |
HIX, DIETER;THYES, MARCO;KLEIN, PETER |
分类号 |
A61K31/517;A61P9/12;C07D405/12;C07D405/14;(IPC1-7):C07D405/14;A61K31/505 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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