COMPETITIVE INHIBITORS OF GLYOXALASE I AND METHOD OF GENERATING SUCH COMPETITIVE INHIBITORS INSIDE TUMOR CELLS

摘要

The present invention provides a compound having structure (I) wherein S* is S=O or O=S=O; and wherein R1 is selected from the group consisting of (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with halogen or (C1-C18) alkyl; and wherein R2 is selected from the group consisting of alkyl, (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with hologen or (C1-C18) alkyl. Also provided are various methods of using the compositions of the present invention.