发明名称 |
COMPETITIVE INHIBITORS OF GLYOXALASE I AND METHOD OF GENERATING SUCH COMPETITIVE INHIBITORS INSIDE TUMOR CELLS |
摘要 |
The present invention provides a compound having structure (I) wherein S* is S=O or O=S=O; and wherein R1 is selected from the group consisting of (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with halogen or (C1-C18) alkyl; and wherein R2 is selected from the group consisting of alkyl, (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with hologen or (C1-C18) alkyl. Also provided are various methods of using the compositions of the present invention.
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申请公布号 |
WO9935128(A1) |
申请公布日期 |
1999.07.15 |
申请号 |
WO1999US00255 |
申请日期 |
1999.01.07 |
申请人 |
UNIVERSITY OF MARYLAND AT BALTIMORE COUNTY |
发明人 |
CREIGHTON, DONALD;HAMILTON, DIANA, S.;KAVARANA, MALCOLM, J. |
分类号 |
C07C333/04;C07C333/08;C07C381/14;(IPC1-7):C07C333/00 |
主分类号 |
C07C333/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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